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. 2021 Mar 27;18(11):2251–2261. doi: 10.7150/ijms.56024

Figure 1.

Figure 1

Figure 1

GRP94 mediates cancer progression in vitro and in vivo. (a) Expression level of GRP94 in GRP94-KD and scrambled control cells was evaluated by Western blotting (n=3). Quantitative data was normalized to GAPDH. (b) Cell proliferation of scrambled control and GRP94-KD cells was determined by SRB assay (n=3). (c) In xenograft model, volume of GRP94-KD tumor was smaller than scrambled control tumor (8 mice for each group). (d)Tumor weight of GRP94-KD was less than that of scrambled control. (e) Immunohistochemistry staining (IHC) showed negative reaction in GRP94-KD group and positive reaction in scrambled control group. (*P<0.05, **P <0.01, ****P < 0.0001)