Table 2.
Association between TLS expression and clinicopathological characteristics of tumor patients.
| Clinicopathological parameter | Studies (n) | Patients (n) | OR (95% CI) | P-value | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
| I²% | P-value | Model | |||||
| Age<60 vs. >60 years | 9 | 2593 | 0.91(0.76-1.11) | 0.36 | 18 | 0.28 | Fixed |
| gastric tumor | 2 | 1101 | 1.17(0.85-1.60) | 0.33 | 45 | 0.18 | |
| breast cancer | 2 | 407 | 0.98(0.61-1.59) | 0.94 | 0 | 0.42 | |
| oral squamous cell carcinoma | 2 | 248 | 0.84(0.47-1.50) | 0.55 | 0 | 0.8 | |
| pancreatic ductal carcinoma | 2 | 343 | 0.80(0.44-1.43) | 0.44 | 59 | 0.12 | |
| other tumors | 1 | 494 | 0.69(0.48-1.00) | 0.05 | |||
| Gender (male vs. female) | 9 | 1772 | 1.11(0.87-1.41) | 0.40 | 16 | 0.30 | Fixed |
| hepatocellular carcinoma | 2 | 894 | 1.11(0.76-1.60) | 0.6 | 63 | 0.1 | |
| oral squamous cell carcinoma | 2 | 248 | 1.27(0.68-2.34) | 0.45 | 0 | 0.75 | |
| pancreatic ductal carcinoma | 2 | 355 | 1.19(0.68-2.07) | 0.55 | 27 | 0.24 | |
| other tumors | 3 | 275 | 0.97(0.58-1.61) | 0.89 | 64 | 0.06 | |
| Tumor size (small vs. large) | 6 | 2555 | 1.52(1.27-1.81) | <0.00001 | 48 | 0.09 | Fixed |
| hepatocellular carcinoma | 2 | 895 | 1.55(1.17-2.04) | 0.002 | 0 | 0.49 | |
| gastric cancer | 2 | 1101 | 1.48(1.16-1.89) | 0.002 | 86 | 0.0007 | |
| other tumors | 2 | 559 | 1.65(0.89-3.05) | 0.11 | 46 | 0.17 | |
| ki67 expressions (low vs. high) | 3 | 509 | 0.71(0.29-1.75) | 0.46 | 79 | 0.009 | Random |
| Tumor-infiltrating lymphocytes level (TILs) (low vs. high) | 3 | 635 | 0.15(0.10-0.21) | <0.00001 | 44 | 0.17 | Fixed |
| breast cancer | 3 | 635 | 0.15(0.10-0.22) | <0.00002 | 44 | 0.17 | |
| T stage (T1-T2 vs. T3-T4) | 8 | 1236 | 1.42(0.72-2.81) | 0.31 | 55 | 0.03 | Random |
| colorectal cancer | 2 | 170 | 1.68(0.14-19.58) | 0.68 | 44 | 0.18 | |
| oral squamous cell carcinoma | 2 | 237 | 1.48(0.16-13.54) | 0.73 | 85 | 0.01 | |
| pancreatic ductal carcinoma | 2 | 355 | 3.51(1.06-11.63) | 0.04 | 0 | 0.52 | |
| other tumors | 2 | 474 | 0.93(0.41-2.11) | 0.87 | 44 | 0.18 | |
| N stage (N0 vs. >N0) | 9 | 1510 | 0.95(0.62-1.45) | 0.81 | 60 | 0.01 | Random |
| colorectal cancer | 2 | 170 | 4.48(1.56-12.85) | 0.005 | 0 | 0.99 | |
| breast cancer | 2 | 527 | 0.64(0.44-0.92) | 0.02 | 0 | 0.77 | |
| oral squamous cell carcinoma | 2 | 232 | 0.90(0.16-4.89) | 0.9 | 79 | 0.03 | |
| pancreatic ductal carcinoma | 2 | 355 | 0.97(0.40-2.34) | 0.94 | 43 | 0.19 | |
| other tumors | 1 | 226 | 0.94(0.56-1.59) | 0.83 | |||
| M stage (M0 vs. M1) | 3 | 430 | 0.49(0.17-1.38) | 0.18 | 0 | 0.81 | Fixed |
| pancreatic ductal carcinoma | 2 | 355 | 0.46(0.15-1.40) | 0.17 | 0 | 0.60 | |
| other tumors | 1 | 75 | 0.91(0.04-23.43) | 0.96 | |||
| Grade (I-II vs. III-IV) | 11 | 2608 | 0.89(0.54-1.46) | 0.64 | 76 | <0.00001 | Random |
| colorectal cancer | 2 | 170 | 8.64(2.48-30.09) | 0.0007 | 0 | 0.47 | |
| breast cancer | 3 | 620 | 0.31(0.21-0.47) | <0.00001 | 0 | 0.38 | |
| gastric tumor | 2 | 1140 | 0.87(0.69-1.10) | 0.26 | 0 | 0.91 | |
| pancreatic ductal carcinoma | 2 | 355 | 2.22(0.62-7.92) | 0.22 | 0 | 0.76 | |
| other tumors | 2 | 323 | 1.02(0.60-1.75) | 0.93 | 0 | 0.76 | |
Abbreviations: vs: versus; T: primary tumor range; N: lymph node; M: distance metastasis; OR: odds ratios.