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. 2021 Apr 22;11:639600. doi: 10.3389/fonc.2021.639600

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Copyright © 2021 He, Liu, Yang, Bi, Zhou, Zhang, Jin, Liang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of mRNA and protein expression level. The mRNA expression level of VWF (A) and SPP1 (B) in HBE, H1299, H1975, and A549 cell lines. **p<0.01,***p<0.001,****p<0.0001. And protein expression of VWF and SPP1 validated using western blotting (C). Each experiment was carried out three times. A representative immunohistochemistry image of VWF in LUAD and adjacent non-tumor tissues. Scale bar = 100 µm (D). The scatter plot of immunohistochemistry score of LUAD and matched normal tissues. (E). ***p< 0.001.