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. 2021 Apr 22;11:669066. doi: 10.3389/fonc.2021.669066

Figure 7.

Figure 7

Dectin-1 deficiency reduces immunosuppressive cells and OSCC tumor burden. Statistics showing the body weight loss, comparing the indicated groups (A). Tongue tissues were processed for immunohistochemistry (IHC) and flow cytometry at 23 weeks after 4-NQO administration. Statistics showing the number of IL-1β+ cells in the entire field of 200X IHC image (B). Flow cytometry-based statistics showing % increase in Tregs in 4-NQO treated mice compared to Veh. controls (C), Treg:CD8 ratio (D), the % of PD-1 and IFN-γ expressing CD8 cells (E), the % of CD11b and Ly6G expressing CD45+ cells (F), and the statistical analysis for all of the above (G). H&E immunohistochemistry of tongue (H), and blinded OSCC scoring (I). (Mann-Whitney test except for (B), where t-test with Welch’s correction was performed, *P < 0.05, **P < 0.05, ***P < 0.005, ****P < 0.0005, n.s, non-significant).