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. 2021 Apr 22;12:676396. doi: 10.3389/fphar.2021.676396

FIGURE 3.

FIGURE 3

RRx-001 significantly increased the grade of bone marrow cellularity but not megakaryocytes after sublethal total body irradiation (A) Pretreatment with 10 mg/kg RRx-001 significantly increased the grade of bone marrow cellularity (grade 1: ≤10%; grade 2: 11–30%; grade 3: 31–60%; grade 4: 61–89%; grade 5: ≥90%) on day 14 after irradiation compared to the vehicle control; ***p < 0.0001 (B) In the sham-treated groups, RRx-001 had a significant increase in average megakaryocyte number per 10 HPF compared to the vehicle control on day 14; *p = 0.041. However, in the irradiated groups on day 21 there was a significant spike in megakaryocyte numbers in the vehicle-treated group compared to the RRx-001-treated group; *p = 0.029. Error bars show mean ± SEM. Significance was determined using a parametric test consisting of a general linear model ANOVA and the Kruskal–Wallis nonparametric test. N = 3 mice/group/time point (60 mice total) per experiment. The experiment was performed in duplicate (120 mice total).