Table 2.
Laboratory findings of the patients with MIS-C
| Total patient | Mild MIS-C (1) | Moderate MIS-C (2) | Severe MIS-C (3) | p value¥ | p value€ | |
|---|---|---|---|---|---|---|
| Variable | n = 36 (100%) | n = 13 (36.1%) | n = 6 (16.7%) | n = 17 (47.2%) | ||
| WBC (K/μL) | 10,700 ± 4842 | 11,162 ± 6092 | 12,583 ± 4495 | 9682 ± 3813 | 0.373 | |
| Neutrophil count (K/μL)* | 7650 (6200) | 7400 (7150) | 10,450 (7400) | 7500 (5450) | 0.628 | |
| Lymphocyte count (K/μL)* | 1650 (1575) | 1900 (1100) | 2000 (1175) | 1000 (1450) | 0.026 |
1 vs. 2:0.69 1 vs. 3:0.032 2 vs. 3:0.023 |
| Platelet count (K/μL) | 199,190 ± 86,355 | 217,310 ± 82,820 | 286,670 ± 110,176 | 154,470 ± 4597 | 0.005 |
1 vs. 2:0.114 1 vs. 3:0.016 2 vs. 3:0.009 |
| ESR (> 20 mm/h)* | 49 (56) | 42 (60) | 66 (53) | 51 (45) | 0.568 | |
| C-reactive protein (> 8 mg/L)* | 148 (158) | 91.5 (153) | 71.6 (230) | 195 (165) | 0.168 | |
| Procalcitonin (> 0.5 ng/L)* | 1.6 (8.2) | 1.5 (2.3) | 0.3 (1.4) | 4.8 (27) | 0.001 |
1 vs. 2:0.188 1 vs. 3:0.006 2 vs. 3:0.003 |
| IL-6 (> 6.4 pg/mL)* | 76. (132) | 47 (113) | 23.7 (67) | 146 (214) | 0.006 |
1 vs. 2:0.161 1 vs. 3:0.042 2 vs. 3:0.003 |
| Troponin (> 17.5 ng/L) * | 9.4 (28) | 6.6 (12) | 6.65 (94) | 25.6 (40) | 0.047 |
1 vs. 2:0.9 1 vs. 3:0.022 2 vs. 3:0.09 |
| Pro-BNP (> 125 pg/mL)* | 2539 (7125) | 1500 (2230) | 543 (1691) | 7834 (17,932) | 0.003 |
1 vs. 2:0.216 1 vs. 3:0.008 2 vs. 3:0.005 |
| LDH (U/L)* | 312 (100) | 284 (129) | 281 (70) | 352 (101) | 0.118 | |
| INR (> 1.2) | 1.20 ± 0.23 | 1.27 ± 0.358 | 1.19 ± 0.153 | 1.15 ± 0.14 | 0.836 | |
| D-dimer (> 500 ng/mL)* | 2270 (2617) | 2061 (2278) | 764 (1520) | 3240 (2504) | 0.01 |
1 vs. 2:0.096 1 vs. 3:0.052 2 vs. 3:0.008 |
| Ferritin (> 336 ng/mL) * | 285 (519) | 258 (313) | 82.20 (102) | 601 (517) | < 0.0001 |
1 vs. 2:0.079 1 vs. 3:0.002 2 vs. 3:0.001 |
| AST (> 50 U/L)* | 33.5 (23) | 30 (25) | 26.5 (18) | 35 (40) | 0.241 | |
| ALT (> 50 U/L) * | 26 (24) | 15 (16.5) | 26.5 (14) | 34 (38) | 0.030 |
1 vs. 2:0.792 1 vs. 3:0.031 2 vs. 3:0.03 |
| Albumin (< 3.5 g/dL) | 3.47 ± 0.65 | 3.66 ± 0.63 | 3.71 ± 0.49 | 3.24 ± 0.66 | 0.097 | |
| Sodium (< 135 mEq/L) | 134 ± 4 | 135.3 ± 3.3 | 135.8 ± 2.92 | 132.4 ± 4.51 | 0.162 | |
| Urea (mg/dL)* | 21 (11) | 19 (12.5) | 20 (7) | 25 (16) | 0.173 | |
| Creatinine (mg/dL) | 0.498 ± 0.211 | 0.412 ± 0.14 | 0.455 ± 0.149 | 0.578 ± 0.24 | 0.103 | |
| SARS-CoV-2 IgG level* | 32.17 (5–208) | 30.08 (6–69) | 29.20 (5–45) | 43 (7–208) | 0.28 |
Categorical variables were presented as number and percentage. If data were distributed normally, parameters were reported as mean ± standard deviation; if not, they were presented as median with IQR. Results were compared using the Kruskal–Wallis test followed by the Bonferroni-corrected Mann–Whitney U test. Significance was determined by p < 0.05 for the Kruskal–Wallis test and p < 0.016 (p = 0.05/3) for the Bonferroni correction. Statistically significant differences are highlighted in bold
¥Kruskal–Wallis test, €Bonferroni-corrected Mann–Whitney U test