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(A) Observation of the abdominal cavity metastasis in nude mice in each group. (B) Immunohistochemistry detect the expression of HIF-1α, MMP-2, TGF-β, Twist, N-cad, and E-cad in metastatic tumor tissues of nude mice (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 compared with Control group; ##p<0.01 compared with shHIF-1α group).
