Table 1.
Relationship between KNSTRN expression and clinicopathological characteristics in patients with lung adenocarcinoma.
| Characters | level | Low expression of KNSTRN | High expression of KNSTRN | p | test |
|---|---|---|---|---|---|
| n | 256 | 257 | |||
| OS event (%) | Alive | 180 (70.3) | 146 (56.8) | 0.002 | |
| Dead | 76 (29.7) | 111 (43.2) | |||
| T stage (%) | T1 | 104 (40.6) | 64 (24.9) | <0.001 | exact |
| T2 | 125 (48.8) | 151 (58.8) | |||
| T3 | 21 (8.2) | 26 (10.1) | |||
| T4 | 4 (1.6) | 15 (5.8) | |||
| NA | 2 (0.8) | 1 (0.4) | |||
| N stage (%) | N0 | 179 (69.9) | 151 (58.8) | 0.002 | exact |
| N1 | 45 (17.6) | 50 (19.4) | |||
| N2 | 23 (9.0) | 51 (19.8) | |||
| N3 | 1 (0.4) | 1 (0.4) | |||
| NA | 8 (3.1) | 4 (1.6) | |||
| M stage (%) | M0 | 164 (64.1) | 180 (70.0) | 0.090 | |
| M1 | 7 (2.7) | 18 (7.0) | |||
| NA | 85 (33.2) | 59 (23.0) | |||
| Clinical stage (%) | Stage I | 156 (60.9) | 118 (45.9) | <0.001 | |
| Stage II | 60 (23.4) | 61 (23.7) | |||
| Stage III | 27 (10.6) | 57 (22.2) | |||
| Stage IV | 8 (3.1) | 18 (7.0) | |||
| NA | 5 (2.0) | 3 (1.2) | |||
| Tumor status (%) | Tumor free | 157 (61.3) | 131 (51.0) | 0.080 | |
| With tumor | 77 (30.1) | 92 (35.8) | |||
| NA | 22 (8.6) | 34 (13.2) | |||
| Primary therapy outcome (%) | PD | 23 (9.0) | 45 (17.5) | 0.003 | exact |
| SD | 23 (9.0) | 14 (5.4) | |||
| PR | 4 (1.6) | 2 (0.8) | |||
| CR | 177 (69.1) | 138 (53.7) | |||
| NA | 29 (11.3) | 58 (22.6) | |||
| Age (%) | < 65 | 98 (38.3) | 122 (47.4) | 0.025 | |
| >= 65 | 151 (59.0) | 123 (47.9) | |||
| NA | 7 (2.7) | 12 (4.7) | |||
| Gender (%) | Female | 158 (61.7) | 118 (45.9) | <0.001 | |
| Male | 98 (38.3) | 139 (54.1) | |||
| Anatomic subdivision (%) | Left | 107 (41.8) | 92 (35.8) | 0.257 | |
| Right | 144 (56.2) | 155 (60.3) | |||
| NA | 5 (2.0) | 10 (3.9) | |||
| Smoking status (%) | Non-smoker | 46 (18.0) | 28 (10.9) | 0.028 | |
| Smoker | 202 (78.9) | 223 (86.8) | |||
| NA | 8 (3.1) | 6 (2.3) | |||
| TP53 mutation (%) | No | 165 (64.4) | 102 (39.7) | <0.001 | |
| Yes | 89 (34.8) | 152 (59.1) | |||
| NA | 2 (0.8) | 3 (1.2) |
OS: Overall Survival; NA: Not Available