Table 4.
Frequency of HLA-DRB1 genotype between control, COVID-19 infected and fatal groups. Data was analyzed using the chi-squared test or Fisher's exact test, in case of having a frequency of less than 5 in one or more of the cells at p < 0.05. ⱶChi-squared test, *Fisher's exact test, NA: Not applicable. Significant p values are in bold.
| Control N = 270 N (%) |
COVID-19 infected N = 270 N (%) |
Fatal N = 58 N (%) |
Control vs. COVID-19 infected P value |
Control vs. fatal P value |
COVID-19 Infected vs. fatal P value |
|
|---|---|---|---|---|---|---|
| DRB1*01 | 9 (3.3) | 9 (3.3) | 3 (5.2) | NA | 0.359* | 0.300* |
| DRB1*03 | 43 (15.9) | 41 (15.1) | 8 (13.8) | 0.812ⱶ | 0.684ⱶ | 0.739ⱶ |
| DRB1*04 | 74 (27.4) | 44 (16.3) | 7 (12.1) | 0.002ⱶ | 0.014ⱶ | 0.325ⱶ |
| DRB1*07 | 30 (11.1) | 42 (15.6) | 11 (19.0) | 0.129ⱶ | 0.101ⱶ | 0.419ⱶ |
| DRB1*08 | 2 (0.7) | 13 (4.8) | 1 (1.7) | 0.004* | 0.433* | 0.189* |
| DRB1*09 | 0 (0.0) | 4 (1.5) | 1 (1.7) | 0.176* | 0.177* | 0.622* |
| DRB1*10 | 11 (4.1) | 7 (2.6) | 1 (1.7) | 0.338ⱶ | 0.341* | 0.535* |
| DRB1*11 | 26 (9.6) | 23 (8.5) | 7 (12.1) | 0.653ⱶ | 0.575ⱶ | 0.274ⱶ |
| DRB1*12 | 2 (0.7) | 4 (1.5) | 1 (1.7) | 0.412* | 0.443* | 0.622* |
| DRB1*13 | 22 (8.1) | 35 (13.0) | 7 (12.1) | 0.687ⱶ | 0.340ⱶ | 0.819ⱶ |
| DRB1*14 | 1 (0.4) | 2 (0.7) | 0 (0.0) | 0.563* | 0.823* | 0.616* |
| DRB1*15 | 25 (9.3) | 24 (8.9) | 6 (10.3) | 0.881ⱶ | 0.798ⱶ | 0.660ⱶ |
| DRB1*16 | 25 (9.3) | 22 (8.1) | 5 (8.6) | 0.647ⱶ. | 0.878ⱶ | 0.882ⱶ |