Figure 1.

Prespecified sequence of events. (1) One year before the index exposure; (2) Index visit (any meta-visit with a diagnosis of bipolar disorder); (3) Index exposure (the first day of exposure [drugs of interest or no drugs of interest] observable on the last day of the index visit); (4) Time-varying drug exposure period (series of time intervals in which distinct regimens [including “no drug”] were prescribed); (5) Outcome (the first meta-visit with coded and/or imputed self-harm or a censoring event).