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. 2021 Apr 21;8(4):e24522. doi: 10.2196/24522

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©Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Raymond Lauve, Nathaniel G Hurwitz, Aurélien J Mazurie, Daniel C Cannon, Yiliang Zhu, Stuart James Nelson, Annette S Crisanti, Berit Kerner, Mauricio Tohen, Douglas J Perkins, Christophe Gerard Lambert. Originally published in JMIR Mental Health (https://mental.jmir.org), 21.04.2021.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Mental Health, is properly cited. The complete bibliographic information, a link to the original publication on http://mental.jmir.org/, as well as this copyright and license information must be included.

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Sensitivity analysis for the “low-risk” and “high-risk” covariates in the second regression model comparing pharmacotherapy (as a single exposure category) and psychotherapy for the risk of self-harm. The X-axis shows 27 covariates and the respective 20%-100% self-harm probability thresholds chosen to impute the outcome. The Y-axis shows the respective hazard ratios (HRs) (colored dots) and CIs (colored lines). Varied intensity magenta is used to represent the range of 20%-40% self-harm probability thresholds, black is used to represent the 50% threshold of the main model, and varied intensity green is used to represent the 60%-100% probability threshold used. The covariate “prior coded self-harm” is separated out with a different HR scale in the far right, since the HR values were extremely high at the 100% (coded) probability threshold. BD: bipolar disorder; CNS: central nervous system; Drug: any of the bipolar disorder drugs of interest.