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. 2021 Apr 21;21(6):486. doi: 10.3892/ol.2021.12747

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Prediction of the circUBAP2-associated axis. (A) A total of 31 and 111 miRNAs were predicted as targets of circUBAP2 using circular RNA interactome and circBank, respectively, and 8 of these miRNAs were co-predicted. (B) The potential regulatory network of circUBAP2 and its targets miR-1244, miR-665, miR-1200, miR-582-3p, miR-637, miR-892b, miR-571 and miR-1305. (C) miR-1244 was the only DEmiR in the miRNA profile GSE76260. (D) A total of 22 mRNAs were predicted as the potential target mRNAs of miR-1244, which were co-predicted using miRDB, TargetScan, miRWalk and TargetMiner. (E) Four co-predicted DEGs (ADD3, DYNC1I1, MAP3K2 and ARHGAP20) in the mRNA expression profile GSE30994. (F) circUBAP2-associated competitive endogenous RNA network. circUBAP2, circular RNA UBAP2; DE, differentially expressed; DEGs, DE genes; miR/miRNA, microRNA; ADD3, adducin 3; DYNC1I1, dynein cytoplasmic 1 intermediate chain 1; ARHGAP20, Rho GTPase activating protein 20; PCa, prostate cancer.