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. 2021 Apr 21;21(6):486. doi: 10.3892/ol.2021.12747

Figure 3.

Figure 3.

Validation of PCa-associated circUBAP2/miR-1244/MAP3K2 axis. (A) MAP3K2 expression was significantly upregulated following miR-1244-knockdown. (B) Putative binding sites of miR-1244 on circUBAP2 and MAP3K2. (C) Expression levels of circUBAP2, miR-1244 and MAP3K2 in clinical PCa and normal tissues. (D) Correlation between circUBAP2, miR-1244 and MAP3K2 expression in clinical tissues of PCa. (E and F) Fluorescence activity was decreased in 293T cells co-transfected with circUBAP2/MAP3K2 reporter plasmid (pGL6-miR plasmid) and miR-1244 mimics. **P<0.01 and ***P<0.001 vs. control. PCa, prostate cancer; circUBAP2, circular RNA UBAP2; miR, microRNA; UTR, untranslated region.