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. 2021 Apr 20;21(6):481. doi: 10.3892/ol.2021.12742

Figure 2.

Figure 2.

Downregulation of miR-188-5p induces cell apoptosis in SW480/OXA cells. (A) Protein expression levels of RASA1, p21, and Ras-GTP in SW480 or SW480/OXA cells transfected with miR-188-5p mimics or inhibitors. (B) Hoechst 33342 staining of SW480 or SW480/OXA cells transfected with miR-188-5p mimics or inhibitor. Scale bar, 100 µm. (C) Apoptosis of SW480 or SW480/OXA cells transfected with miR-188-5p mimics or inhibitor. ***P<0.001 vs. NC mimics; ###P<0.001 vs. NC inhibitor. (D) Cell cycle distribution was analyzed by flow cytometry. ***P<0.001 vs. NC mimics, ###P<0.001 vs. NC inhibitor. miR, microRNA; oxa, oxaliplatin; RASA1, Ras GTPase-activating protein 1; PI, propidium iodide; FITC, fluorescein isothiocyanate; NC, negative control.