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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: J Biomed Mater Res A. 2020 Aug 25;109(6):893–902. doi: 10.1002/jbm.a.37080

FIGURE 4.

FIGURE 4

Anti-MUC4 immune response from sera of mice vaccinated with three MUC4β-based vaccine formulations. (a) Indirect ELISA using MUC4β coated plates. (b) Indirect ELISA using MUC16-coated plates. Significant differences were observed depending on formulation and regimen. Reactivity of CDN + NP combination formulations was significantly higher than that provided by either CDN or NP alone. Reactivity after second immunization is significantly higher than that of the pre-immune control and after single immunization. For both MUC4β- and MUC16-coated plates, OD values at 1:6400 dilution were used to generate the plots. Data were not normalized. Error bars represent SEM. * indicates statistical significance (p < 0.05) between different vaccine formulations. *** indicates statistical significance (p < 0.05) between from secondary immunization to primary immunization and unimmunized group. CDN, cyclic dinucleotide