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. 2021 May 6;22:139. doi: 10.1186/s13059-021-02330-1

Fig. 1.

Fig. 1

A hierarchical strategy for determining whole-chromosome haplotypes. The haplotype phase of parental chromosomes (open and filled rectangles) are represented by the positions of alternate genotypes at heterozygous sites. Megabase-scale haplotype blocks are determined using linkage information (∼10kb range) from linked-reads or long-read sequencing and then concatenated using Hi-C contacts, first within each chromosome arm and then between the p- and q-arms