46-year-old woman with cancer seen on annual screening tomosynthesis examination only.
A and B, Two-dimensional craniocaudal (A) and mediolateral oblique (B) digital mammograms show heterogeneously dense breast tissue.
C and D, Craniocaudal digital breast tomosynthesis image (C) shows spiculated mass (within circle), which has much more subtle appearance on mediolateral oblique image (arrow, D).
E, Close-up of mediolateral oblique digital breast tomosynthesis image in D shows mass (arrow) in detail. Core biopsy and excision revealed 0.7-cm grade 2 invasive ductal carcinoma that was estrogen receptor positive, progesterone receptor positive, and human epidermal growth factor receptor 2 (HER2 [also known as ERBB2]) negative. Sentinel node was negative for metastasis.