13.3. Analysis.

Comparison 13: Additional data tables, Outcome 3: Trials of intralesional bleomycin

Trials of intralesional bleomycin
Study	Intervention	Results	Outcomes
Adalatkhah 2007	Bleomycin vs cryotherapy	Cure rate for bleomycin was statistically better than cryotherapy	Cure in 38/44 (86%) vs 30/44 (68%) at 6 weeks
Bunney 1984	Bleomycin vs placebo	Higher cure rate with bleomycin	Cure in 34/59 (58%) vs 6/59 (10%) warts at 6 weeks. 1 withdrawal with pain
Dhar 2009	Bleomycin vs cryotherapy	Bleomycin more effective	Cure in 37/39 (94.9%) vs 26/34 (76.5%) 8 weeks after last treatment
Hayes 1986	3 different doses of bleomycin used (0.25, 0.5, & 1.0 IU)	No significant difference between treatments. Trend towards higher concentrations being more effective	Cure in 11/15 (73%) vs 21/24 (88%) vs 9/10 (90%) warts at 3 months. Most participants experienced pain irrespective of dose
Munkvad 1983	Bleomycin vs placebo	No difference between treatments. (In fact, significantly higher cure rates with placebo.) Bleomycin not recommended	Cure in 4/22 (bleomycin + saline) (18%) vs 5/36 (bleomycin in oil) (14%) vs 8/19 (saline placebo) (42%) vs 10/22 (oil placebo) (45%) warts at 3 months
Perez 1992	Bleomycin vs placebo	No difference between treatments. Saline cheaper and as effective as a treatment	Cure in 15/16 (94%) and 11/15 (73%) participants at 30 days
Rossi 1981	Bleomycin vs placebo	Bleomycin significantly better	Cure in 31/38 (82%) vs 16/46 (35%) warts at 1 month