13.10. Analysis.

Comparison 13: Additional data tables, Outcome 10: Trials of topical 5‐fluorouracil

Trials of topical 5‐fluorouracil
Study	Intervention	Results	Outcomes
Artese 1994	5‐FU + SA vs cautery	5‐FU better than cautery	Cure in 127/150 (85%) vs 99/150 (66%) at 75 days
Bunney 1973	2% 5‐FU vs 5% 5‐FU vs SA/LA vs idoxuridine	No significant difference between any of these	Cure at 13/28 (46%), 8/15 (53%), 8/16 (50%), and 9/36 (25%) at 12 weeks
Hursthouse 1975	5‐FU vs placebo	5‐FU significantly better	Cure in 29/64 (45%) vs 8/64 (13%) at 4 weeks
Luk 2006	5‐FU + cryotherapy vs cryotherapy	5‐FU treatment added no additional benefit to cryotherapy	Cure in 5‐FU + cryotherapy group was 12/40 vs 17/40, while cure in cryotherapy + 5‐FU treatment group was associated with more blistering (21 vs 14) and pain (19 vs 11)
Salk 2006	5‐FU vs tape	Highly significantly better treatment with 5‐FU compared to tape occlusion	Cure in 17/20 vs 2/20 at 6 months. 5‐FU treatment was associated with more pain (12 vs 9)
Schmidt 1981	5‐FU/SA vs placebo	5‐FU/SA significantly better	Cure in 13/28 (46%) vs 5/27 (19%) at 6 weeks
Wolff 1980	5‐FU/SA vs placebo	5‐FU/SA significantly better	Success in 12/21 (57%) vs 9/21 (43%)