Comparison 2. Cryotherapy vs placebo/no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Cure rate all studies all sites	3	227	Risk Ratio (M‐H, Random, 95% CI)	1.45 [0.65, 3.23]
2.2 Cure rate hands and feet	3	214	Risk Ratio (M‐H, Random, 95% CI)	1.50 [0.66, 3.39]
2.2.1 Hands only	2	104	Risk Ratio (M‐H, Random, 95% CI)	2.63 [0.43, 15.94]
2.2.2 Feet only	2	110	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.26, 3.07]