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. 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3
Trials of topicals containing salicylic acid
Study Interventions Results Outcomes
Abou‐Auda 1987 15% SA patch vs placebo patch SA better than placebo 'Successful treatment' in 27/31 (87%) vs 11/23 (48%) at 12 weeks
Auken 1975 SA/LA vs 'conventional treatment' (anything else or no treatment) No advantage of either approach Cure in 43/84 (51%) vs 54/101 (54%) at 3 months
Bart 1989 SA vs placebo SA better than placebo Cure in 19/28 (68%) vs 7/25 (28%) at 12 weeks
Bruggink 2010 Cryotherapy vs SA vs 'wait and see' Cryotherapy was the most effective treatment, especially for non‐plantar warts Cure in 39%, 24%, and 16% in all warts and 49%, 15%, and 8% in all non‐plantar warts
Bunney 1971 SA vs collodion alone vs callusolve vs 50% podophyllin No significant difference between any of the treatments.
Lower cure rate for mosaic as opposed to simple plantar warts
Cure in 64/76 (84%) vs 50/76 (66%) vs 47/70 (67%) vs 60/74 (81%) at 12 weeks
Bunney 1976c SA vs SA + polyoxyethylene No difference Cure in 55/71 (77%) vs 50/67 (75%) at 12 weeks
Bunney 1976d 10% glutaraldehyde vs SA No difference Cure in 18/38 (47%) vs 19/43 (44%) at 12 weeks
Bunney 1976e 40% SA vs ordinary SA/LA No significant difference Cure in 15/50 (30%) vs 17/43 (40%) at 12 weeks
Felt 1998 Anthralin vs SA/LA Anthralin significantly better than conventional SA/LA Cure in 15/27 (56%) vs 8/31 (26%) at 2 months
Flindt‐Hansen 1984 Anthralin vs SA/LA Anthralin significantly better than conventional SA/LA Cure in 15/27 (56%) vs 8/31 (26%) at 2 months
Parton 1994 Abrasion vs SA Faster cure with abrasion Mean time to cure of 2.1 weeks (2 to 4) vs 18.2 weeks (8 to 38). Itching in 93% of abrasion group.
(100% cure rate with both treatments implied by text)
Spanos 1990 Hypnosis vs SA vs placebo vs no treatment Hypnosis significantly better than all other 3 groups 'Loss of warts' in 6/10 (60%) vs 0/10 (0%) vs 1/10 (10%) vs 3/10 (30%) at 6 weeks
Steele 1988b MCAA + SA vs placebo MCAA/SA more effective than placebo Cure in 19/29 (66%) vs 5/28 (18%) at 6 weeks
Veien 1991 SA/LA with vs without occlusion No difference between the 2 groups. No advantage of occlusions Cure in 48% and 47% at 17 weeks