Trials of topicals containing salicylic acid | |||
Study | Interventions | Results | Outcomes |
Abou‐Auda 1987 | 15% SA patch vs placebo patch | SA better than placebo | 'Successful treatment' in 27/31 (87%) vs 11/23 (48%) at 12 weeks |
Auken 1975 | SA/LA vs 'conventional treatment' (anything else or no treatment) | No advantage of either approach | Cure in 43/84 (51%) vs 54/101 (54%) at 3 months |
Bart 1989 | SA vs placebo | SA better than placebo | Cure in 19/28 (68%) vs 7/25 (28%) at 12 weeks |
Bruggink 2010 | Cryotherapy vs SA vs 'wait and see' | Cryotherapy was the most effective treatment, especially for non‐plantar warts | Cure in 39%, 24%, and 16% in all warts and 49%, 15%, and 8% in all non‐plantar warts |
Bunney 1971 | SA vs collodion alone vs callusolve vs 50% podophyllin | No significant difference between any of the treatments. Lower cure rate for mosaic as opposed to simple plantar warts |
Cure in 64/76 (84%) vs 50/76 (66%) vs 47/70 (67%) vs 60/74 (81%) at 12 weeks |
Bunney 1976c | SA vs SA + polyoxyethylene | No difference | Cure in 55/71 (77%) vs 50/67 (75%) at 12 weeks |
Bunney 1976d | 10% glutaraldehyde vs SA | No difference | Cure in 18/38 (47%) vs 19/43 (44%) at 12 weeks |
Bunney 1976e | 40% SA vs ordinary SA/LA | No significant difference | Cure in 15/50 (30%) vs 17/43 (40%) at 12 weeks |
Felt 1998 | Anthralin vs SA/LA | Anthralin significantly better than conventional SA/LA | Cure in 15/27 (56%) vs 8/31 (26%) at 2 months |
Flindt‐Hansen 1984 | Anthralin vs SA/LA | Anthralin significantly better than conventional SA/LA | Cure in 15/27 (56%) vs 8/31 (26%) at 2 months |
Parton 1994 | Abrasion vs SA | Faster cure with abrasion | Mean time to cure of 2.1 weeks (2 to 4) vs 18.2 weeks (8 to 38). Itching in 93% of abrasion group. (100% cure rate with both treatments implied by text) |
Spanos 1990 | Hypnosis vs SA vs placebo vs no treatment | Hypnosis significantly better than all other 3 groups | 'Loss of warts' in 6/10 (60%) vs 0/10 (0%) vs 1/10 (10%) vs 3/10 (30%) at 6 weeks |
Steele 1988b | MCAA + SA vs placebo | MCAA/SA more effective than placebo | Cure in 19/29 (66%) vs 5/28 (18%) at 6 weeks |
Veien 1991 | SA/LA with vs without occlusion | No difference between the 2 groups. No advantage of occlusions | Cure in 48% and 47% at 17 weeks |