Auken 1975.

Study characteristics
Methods	This study was carried out in a secondary care setting, and it was multicentre. This study was blinded. Intention‐to‐treat analysis was not carried out. This study was conducted in Denmark.
Participants	240 participants were recruited: 55 dropped out. Inclusion criteria of the trial Adults and children Ordinary or refractory wart type not specified Warts on the hands or feet
Interventions	LA/SA (Verucid) 'conventional' treatment (= anything else or no treatment)
Outcomes	Outcomes of the trial Cure at 3 months
Notes	The control group were treated with 3 different treatments. No details were given about the treatment methods or how many participants were treated with each method.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote (page 3): "The trial was carried out as a double‐blind trial with roughly half the patients being treated by the traditional, conservative methods…" "The patients were chosen randomly and only the treating nurse knew which treatment applied to the number the patient had been given". The method of randomisation was not stated.
Allocation concealment (selection bias)	Unclear risk	This was unclear; no details were given.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Only the treating nurse knew which treatment had been given. Comment: Although some attempt at blinding was made, it was unclear if both participants and personnel were blinded adequately. This was judged as unclear.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote (page 3): "After paring away the wart and also removing any remaining ointment (so the preparation could not be seen), one of us was called to assess the result." Comment: This was probably at low risk of bias.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	55/240 participants dropped out: 27 from the intervention group and 28 from the control group. Reasons for dropout were not stated.
Selective reporting (reporting bias)	Low risk	All outcomes were reported.