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. 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3

Aum 2006.

Study characteristics
Methods This study was carried out in a secondary care setting.
The blinding within this study was unclear.
Intention‐to‐treat analysis was not carried out.
This study was conducted in Korea.
Participants 24 participants were recruited.
Inclusion criteria of the trial
  • Adults and children

  • Refractory warts

  • Periungual warts

Interventions
  • Intralesional bleomycin (dose unclear) versus

  • Pulsed dye laser with intralesional bleomycin every 3 weeks.


The total duration of therapy was unclear.
Outcomes Outcomes of the trial
  1. Cure rate

Notes Follow‐up time was unclear.
Recurrence was assessed at 6 months.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk This was described as randomised; the method of randomisation was not clear.
Allocation concealment (selection bias) Unclear risk It was unclear if allocation was concealed; no information was given in the trial report.
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk It was unclear if the study was blinded.
Comment: Blinding was unlikely given the nature of the treatment.
Blinding of outcome assessment (detection bias)
All outcomes High risk It was unclear if the study was blinded.
Incomplete outcome data (attrition bias)
All outcomes Low risk No participants were apparently lost to follow up, but the numbers completing and available for assessment were not given.
Comment: The minimisation of attrition bias was adequate.
Selective reporting (reporting bias) High risk The length of the study was not documented. Tolerability, adverse effects, and practicality of PDL were not reported on.