Felt 1998.
Study characteristics | ||
Methods | This study was carried out in a secondary care setting, and it was open. Intention‐to‐treat analysis was not carried out. This study was conducted in the USA. |
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Participants | 61 participants were recruited: 10 dropped out. Inclusion criteria of the trial
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Interventions |
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Outcomes |
Outcomes of the trial
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Notes | Only 1 index wart was treated in each child. A quote on page 134 related to performance bias: "A similar percentage of children across experimental groups reported use of topical treatments after the initial 8 weeks." The authors commented that "spontaneous regression within 2 years is thought to occur for about half to two thirds of warts"; yet, they used 6 to 18 months as the timeframe for follow up. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Random assignment was conducted by picking a study number from a hat. (page 132) Comment: This was probably adequate. |
Allocation concealment (selection bias) | Unclear risk | It was unclear if any attempt was made to conceal allocation. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | No attempt was made at blinding. |
Blinding of outcome assessment (detection bias) All outcomes | High risk | No attempt was made at blinding. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 51/61 participants completed. Dropouts were distributed across groups. The reasons for dropout were not given. Comment: This was probably adequate. |
Selective reporting (reporting bias) | Unclear risk | All outcomes were reported. |