Martinez 1996.

Study characteristics
Methods	This study was carried out in a primary care setting, and it was open. Intention‐to‐treat analysis was not carried out. This study was conducted in Spain.
Participants	124 participants were recruited: 3 dropped out. Inclusion criteria of the trial Adults and children Ordinary warts Warts anywhere
Interventions	Dimethyl ether propane (DMEP) applied by swab Cotton wool bud cryotherapy, 3 freezes per case at 1‐week intervals
Outcomes	Outcomes of the trial Cure 15 days after last treatment
Notes	The main unit of analysis was warts rather than participants. It was not clear whether warts or participants were randomised. Molluscum and solar keratosis were also included in the study. Liquid nitrogen was applied with gauze.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	This was described as random allocation.
Allocation concealment (selection bias)	Unclear risk	This was unclear; no details were given.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	This was unclear; no details were given.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blind assessment was made by a doctor.
Incomplete outcome data (attrition bias) All outcomes	Low risk	3/124 participants completed (there were 3 voluntary withdrawals and no withdrawals because of adverse effects).
Selective reporting (reporting bias)	Low risk	All outcomes were reported.