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. 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3

Schmidt 1981.

Study characteristics
Methods This study was carried out in a secondary care setting.
This study was blinded.
Intention‐to‐treat analysis was not carried out.
This study was conducted in Denmark.
Participants 60 participants were recruited: 5 dropped out.
Inclusion criteria of the trial
  • Adults

  • Ordinary or refractory warts not specified

  • Warts on the hands or feet

Interventions
  • 5‐FU/SA

  • Placebo (vehicle alone)


Treatment was applied daily for 6 weeks.
Outcomes Outcomes of the trial
  1. Cure (presumably at 6 weeks)

Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk This was described as randomised; no details were given.
Allocation concealment (selection bias) Unclear risk This was unclear; no details were given.
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk This was unclear. This was described as double‐blind; the placebo appeared to be identical.
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk This was unclear; no details were given.
Incomplete outcome data (attrition bias)
All outcomes High risk 5/60 participants completed. The results for 5 dropouts (2/30 Verrumal and 3/30 placebo) "could not be analysed" (page 1). No reasons were given.
Also, it was not stated how many participants were randomised to each group – it was presumed that there were 30 in each group.
Selective reporting (reporting bias) Low risk All outcomes were reported.