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. 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3

Veien 1991.

Study characteristics
Methods This study was carried out in a secondary care setting, and it was open.
Intention‐to‐treat analysis was carried out.
This study was conducted in Denmark.
Participants 250 participants were recruited: 80 dropped out.
Inclusion criteria of the trial
  • Adults and children

  • Ordinary or refractory warts not specified

  • Feet (simple plantar)

Interventions
  • SA/LA with occlusion

  • SA/LA


Applied twice daily for up to 17 weeks.
Outcomes Outcomes of the trial
  1. Cure at 17 weeks

Notes Results were expressed as percentage only.
Higher cure rates in children were noted.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote (page 59): "Groups of ten patients were allocated to one of the two treatments by balanced block randomisation."
Comment: This was probably done.
Allocation concealment (selection bias) Unclear risk This was unclear
Blinding of participants and personnel (performance bias)
All outcomes High risk This was described as open.
Blinding of outcome assessment (detection bias)
All outcomes High risk This was described as open.
Incomplete outcome data (attrition bias)
All outcomes High risk 170/250 participants completed. There was a high dropout rate (n = 80). Dropout related to therapy was more common among participants treated with the keratolytic agent and occlusion (n = 18) than among participants treated with the keratolytic agent alone (n = 9).
The results were presented using an intention‐to‐treat analysis, but percentages were given rather than participant numbers.
Selective reporting (reporting bias) Low risk All outcomes were reported.