Veien 1991.
Study characteristics | ||
Methods | This study was carried out in a secondary care setting, and it was open. Intention‐to‐treat analysis was carried out. This study was conducted in Denmark. |
|
Participants | 250 participants were recruited: 80 dropped out. Inclusion criteria of the trial
|
|
Interventions |
Applied twice daily for up to 17 weeks. |
|
Outcomes |
Outcomes of the trial
|
|
Notes | Results were expressed as percentage only. Higher cure rates in children were noted. |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Quote (page 59): "Groups of ten patients were allocated to one of the two treatments by balanced block randomisation." Comment: This was probably done. |
Allocation concealment (selection bias) | Unclear risk | This was unclear |
Blinding of participants and personnel (performance bias) All outcomes | High risk | This was described as open. |
Blinding of outcome assessment (detection bias) All outcomes | High risk | This was described as open. |
Incomplete outcome data (attrition bias) All outcomes | High risk | 170/250 participants completed. There was a high dropout rate (n = 80). Dropout related to therapy was more common among participants treated with the keratolytic agent and occlusion (n = 18) than among participants treated with the keratolytic agent alone (n = 9). The results were presented using an intention‐to‐treat analysis, but percentages were given rather than participant numbers. |
Selective reporting (reporting bias) | Low risk | All outcomes were reported. |