Fig. 1.

Different molecular alterations involved in tumor reversion. Molecular mechanism of tumor reversion involving different alternations including PTMs such as phosphorylation, glycosylation, and other molecular changes such as microRNAs, transcription factors, RNA splicing events, the impact of the tumor microenvironment, tumor-associated macrophages, and epigenetic modifications. The arrow with an upward direction (↑) denotes an increase in the expression, and the arrow with a downward direction (↓) denotes a decrease in the expression. In the figure, gene symbols in italic means denoting gene/mRNA, and non-italic means denoting protein