Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 6;23:136. doi: 10.1186/s13075-021-02510-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Upregulation of the molecules involved in integrin-mediated cell adhesion in AAV. a Volcano plot of 3770 differentially expressed genes between patients with AAV and the healthy controls (HCs) (fold change > 1.3, adjusted P < 0.05). b Top five pathways that were differentially regulated between patients with AAV and HCs. c Z-score variance of representative genes within each integrin family among patients with each type of vasculitis and the HCs, are shown. *P < 0.05 using the Kruskal-Wallis test. MPA, microscopic polyangiitis; GPA, granulomatosis with polyangiitis; EGPA, eosinophilic polyangiitis; RV, rheumatoid vasculitis; PAN, polyarteritis nodosa; TAK, Takayasu arteritis; ILK, integrin-linked kinase; ITGAM, integrin alpha M; ITFG1, integrin alpha FG-GAP repeat containing 1; ITGB3, integrin beta 3; ITGA2B, integrin alpha 2b; ITGB2, integrin beta 2