Table 1.
Baseline characteristics of patients, assessed using FACS analysis
| Variable | AAV | LVV | PAN | HC |
|---|---|---|---|---|
| n = 48 | n = 26 | n = 4 | n = 17 | |
| Baseline characteristics | ||||
| Age, years | 70 (57–80) | 67 (47–72) | 64 (48–72) | 43 (32–56) |
| Male, n (%) | 15 (31) | 14 (54) | 1 (25) | 5 (29) |
| Race, Japanese, n (%) | 48 (100) | 26 (100) | 4 (100) | 17 (100) |
| MPA/GPA/EGPA, n | 20/19/9 | – | – | – |
| GCA/TAK, n | – | 15/11 | – | – |
| Newly diagnosed/major relapse, n | 45/3 | 24/2 | 4/0 | – |
| BVAS | 12 (8–18) | 3 (3–6) | 15 (12–19) | – |
| Organ involvement | ||||
| Systemic, n (%) | 34 (71) | 23 (88) | 2 (50) | – |
| Skin, n (%) | 5 (10) | 1 (4) | 3 (75) | – |
| Mucous membranes/eyes, n (%) | 5 (10) | 0 (0) | 0 (0) | – |
| Ear, nose, throat, n (%) | 22 (46) | 0 (0) | 0 (0) | – |
| Chest, n (%) | 28 (58) | 0 (0) | 1 (25) | – |
| Vascular, n (%) | 3 (6) | 9 (35) | 1 (25) | – |
| Renal, n (%) | 17 (35) | 3 (12) | 1 (25) | – |
| Nervous system, n (%) | 20 (42) | 0 (0) | 3 (75) | – |
| Laboratory test | ||||
| ESR, mm/h | 87 (40–121) | 109 (59–122) | 71 (33–112) | – |
| White blood cells, 103 cells/μL | 9.5 (7.0–13) | 9.5 (7.0–14) | 7.7 (6.6–9.1) | – |
| Neutrophils, 103 cells/μL | 6.2 (4.4–8.4) | 5.4 (4.6–7.0) | 6.1 (2.6–8.4) | – |
| Lymphocytes, 103 cells/μL | 1.5 (1.0–1.8) | 1.4 (1.1–1.8) | 1.1 (0.8–1.6) | – |
| Monocytes, cells/μL | 414 (308–623) | 460 (343–565) | 444 (235–737) | – |
| Eosinophils, cells/μL | 223 (116–814) | 119 (67–192) | 109 (7–755) | – |
| Haemoglobin, g/dL | 11 (9.6–13) | 11 (10–12) | 12 (11–13) | – |
| Platelets, 104 cells/μL | 34 (25–41) | 34 (29–42) | 28 (18–36) | – |
| CRP, mg/dL | 3.9 (0.7–8) | 4.8 (2.4–6.5) | 0.8 (0.3–5.2) | – |
| IgG, mg/dL | 1648 (1120 − 1905) | 1437 (1140–1690) | 1325 (1124–2223) | – |
| MPO-ANCA-/PR3-ANCA-positive/ANCA-negative, n | 34/8/6 | 1/0/25 | 0/0/4 | – |
| MPO-ANCA titre, U/mL | 41 (13–171), n = 34 | 28, n = 1 | – | – |
| PR3-ANCA titre, U/mL | 14 (10–39), n = 8 | – | – | – |
| Rheumatoid factor positive, n (%) | 37 (79) | 2 (8) | 1 (25) | – |
| Rheumatoid factor, IU/mL | 65 (32–141) | 29 (16–42) | 41, n = 1 | – |
AAV ANCA-associated vasculitis, MPA microscopic polyangiitis, GPA granulomatosis with polyangiitis, EGPA eosinophilic granulomatosis with polyangiitis, LVV large-vessel vasculitis, GCA giant cell arteritis, TAK Takayasu arteritis, PAN polyarteritis nodosa, BVAS Birmingham vasculitis activity score, ESR erythrocyte sedimentation rate, CRP C-reactive protein, MPO myeloperoxidase, PR3 proteinase 3