Table 1.
The role of STAT3 in regulating signaling proteins in immnue cells
| Immune cells | Proteins | Relathionship with STAT3 | References |
|---|---|---|---|
| MDSCs | IDO | MDSCs-activated STAT3 suppressed the T cell expansion and Th1 polarization via the IDO manner | [37] |
| IRF-8 | STAT3 downregulted the IRF-8 expression and promoted the MDSCs formation | [44] | |
| G-CSF | G-CSF mediated the STAT3/IRF-8 axis functions in MDSCs | [45] | |
| IL-6 | IL-6 stimulated STAT3 phosphorylation in MDSCs | [48] | |
| S100A8/A9 | STAT3 stimulated the S100A8/A9-mediated ROS, then suppressed CD4+ T cells accumulation | [59] | |
| Macrophages | CD206/Arg-1/PTGS2 | STAT3 inhibition suppressed these markers expression | [64, 73] |
| HA | HA actived the STAT3 cascade | [72] | |
| A-FABP | A-FABP stimulated the STAT3 activation by promoting IL-6 production | [67] | |
| HIF-1α/TGF-β1 | STAT3 upregulated HIF-1α/TGF-β1 expression, and influenced angiogenesis, tumor cells proliferation and metastasis | [82] | |
| PD-L1 | STAT3 promoted the PD-L1 secretion on macrophages of tumor milieu | [87] | |
| Dendritic Cells | PKCβII/PRKCB2 | STAT3 reduce the PKCβII protein and PRKCB2 expression and suppressed DCs generation | [98] |
| HER-2/neu | STAT3 inhibition downregulated the tumor surface HER-2/neu expression | [103] | |
| IL-10 | IL-10-related signaling plays an important role in STAT3-elicited cDCs immunosuppressive response | [105] | |
| FLT3L | FLT3L promoted DCs proliferation via STAT3-dependent manners | [111] | |
| Tcf4 | STAT3 interacted with Tcf4 promoters and increased the pDCs population | [110] | |
| CD4 + T cells | IL-10 | STAT3 increased the IL-10 expression and counteracted CD4 + T cells tumoricidal function | [34] |
| Tregs | Foxp3 | STAT3 directly regulated the expression of Foxp3, and promoted the Tregs generation and immunosuppressive abilities | [138] |
| IDO1 | STAT3-mediated IDO1 expression increased the Foxp3+ Tregs in tumor milieu | [150] | |
| CD8 + T cells | INF-α/β | STAT3-blocking induced INF-α/β production and triggered CD8+ T cells responses | [165, 167] |
| GAPDH/HK2 | STAT3 activation repressed GAPDH/HK2, which were critical glycolic indicators for T cells | [172, 174] | |
| FGFR4 | Genetic instability of FGFR4 enhanced the STAT3 activation and possibly suppressed CD8+ T cells infiltration | [137] |