Table 3.

Complications of the included studies

Study	Treatment	Patients	Related complications
Matsumoto, 2015 [17]	NAC	15	Grade 3–4 adverse events: 2 neutropenia and 1 diarrhea
	NACRT	109	NA
Okuyama, 2018 [18]	NAC	27	Grade 3–4 adverse events: no; Frequent toxic events:grade 1 neutropenia
	NACRT	28	Grade 3–4 adverse events: no; Frequent toxic events: grade 1 diarrhea
Deng, 2019 [29]	NAC	152	Grade 3/4 toxicities: leukopenia 9; neutropenia 15; nausea/vomiting 4; diarrhea 12
	NACRT	292	Grade 3/4 toxicities: leukopenia 48; neutropenia 40; nausea/vomiting 13; diarrhea 35; radiation dermatitis 54; radiation proctitis 35;

Note: NAC neoadjuvant chemotherapy without radiation, NACRT neoadjuvant chemoradiation therap, NA not available