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. 2021 May 6;12:276. doi: 10.1186/s13287-021-02355-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — UMSC are capable of uptake and release GALNS enzyme. a Specific activity of UMSC and deficient fibroblast lysate when cultured in rhGALNS-supplemented media. Both cells showed a strong increase in GALNS activity from 5h to 24h. After the addition of mannose-6-phosphate, both cells showed a decrease in activity, with UMSC showing an 80–90% reduction, and the fibroblasts having a 65–85% reduction after 24 h. b Specific activity of fibroblasts co-cultured with UMSC, normalized to fibroblasts cultured without UMSC. After an initial delay, the fibroblasts displayed a 25% increase in GALNS activity on days 3 and 5, then returning to baseline on day 7. Error bars: mean ± SD. (*P < 0.05, ***P < 0.001, two-tailed unpaired t test with Welch’s correction)