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. 2021 Feb 25;5(6):bvab030. doi: 10.1210/jendso/bvab030

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Effect of predictive enrichment markers (PEM) on annualized height velocities (AHV) (means and SD) by treatment and PEM groups. T-tests were used to test for statistical significance. The AHV is shown for all children in the left panel, where AHV is increased in response to LUM-201 versus placebo, but the response is greater with rhGH treatment. In the middle panel, the AHV in the PEM-negative children is not increased with LUM-201 treatment but with rhGH treatment is even greater than in the all-subject group. In contrast, in the right panel in PEM-positive children, both LUM-201 and rhGH increase AHV but the response to the 2 treatments is not different.