Table 3.

Effect of PEM on Mean (SD) AHV by Treatment and PEM Groups

Dose	All subjects	PEM-positive peak GH ≥5 ng/mL and baseline IGF-I > 30 ng/mL	PEM-negative peak GH <5 ng/mL and/or baseline IGF-I ≤ 30 ng/mL	P value PEM-positive vs PEM-negative a
LUM-201	6.0 (1.9)	6.2 (1.8)	5.8 (2.1)	0.60
0.4 mg/kg/day	n = 22	n = 12	n = 10
LUM-201	6.9 (1.9)	7.7 (1.3)	5.4 (2.0)	0.0025
0.8 mg/kg/day	n = 24	n = 15	n = 9
rhGH	11.4 (4.0)	8.8 (1.8)	14.0 (4.1)	0.0013
0.3 mg/kg/week	n = 20	n = 11	n = 9

Abbreviations: AHV, annualized height velocity; GH, growth hormone; IGF-I, insulin-like growth factor I; PEM, predictive enrichment marker; rhGH, recombinant human growth hormone.

^aPaired t-tests were used to test for statistical significance.