Table 2.
Trans-ethnic meta-analysis of candidate SNPs.
| CHR | SNP | BP | Effect allele | P_value | OR (95% CI) | P_heterogeneity | I2 | Model |
|---|---|---|---|---|---|---|---|---|
| 19 | rs56117924 | 36,334,182 | A | 2.73E-07 | 1.76 (1.42-2.18) | 7.51E-02 | 45.66 | Random-effect |
| 19 | rs2073901 | 36,334,485 | A | 1.03E-20 | 2.04 (1.76-2.38) | 4.09E-01 | 2.04 | Fixed-effect |
| 19 | rs412175 | 36,342,103 | C | 6.21E-05 | 1.52 (1.24-1.87) | 1.58E-02 | 55.80 | Random-effect |
| 19 | rs2285450 | 36,342,267 | A | 6.71E-28 | 1.88 (1.68-2.11) | 1.58E-01 | 33.85 | Fixed-effect |
| 19 | rs404299 | 36,349,752 | A | 8.64E-04 | 1.56 (1.20-2.03) | 1.21E-04 | 72.92 | Random-effect |
| 9 | rs4979462 | 117,567,013 | T | 5.40E-11 | 1.33 (1.22-1.44) | 5.16E-01 | 0.00 | Fixed-effect |
| 9 | rs6478109 | 117,568,766 | A | 7.86E-04 | 0.78 (0.68-0.90) | 7.01E-02 | 43.21 | Random-effect |
| 18 | rs8086340 | 60,006,978 | C | 4.58E-02 | 0.88 (0.77-1.00) | 3.28E-02 | 50.57 | Random-effect |
| 18 | rs34213471 | 60,008,436 | A | 5.61E-02 | 1.22 (0.99-1.50) | 9.63E-02 | 39.23 | Random-effect |
SNP: Single nucleotide polymorphism. BP: Physical position according to Hg19. CHR: Chromosome.
OR: Odds ratio. 95% CI: 95% confidence interval. P heterogeneity: P-value of Cochran Q test for heterogeneity. I2: Percentage of total variation across studies due to heterogeneity. Model: Meta-analysis method used. Fixed-effect: Inverse-variance method based on a fixed-effects model. Random-effect: Inverse-variance method based on a random-effects model