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. 2021 Mar 9;30(6):485–499. doi: 10.1093/hmg/ddab064

Figure 2.

Figure 2

Expression data from PDAC samples corroborate the expression patterns seen in PANC-1s. (A) Expression analysis of the TCGA pancreatic adenocarcinoma sample data set indicate that genes upregulated following siRNA knockdown of SOX9 in PANC-1s tend to cluster together and are lowly expressed in these ex vivo samples. Furthermore, downregulated genes with SOX9 knockdown in PANC-1s tend to cluster together and with SOX9 and are highly expressed. (B) At an individual gene level, CCDC13, a gene that is upregulated following SOX9 knockdown, is negatively correlated with SOX9 expression, suggesting that SOX9 negatively regulates this gene. (C) Conversely, ESRP1, a gene that is downregulated following SOX9 knockdown, is positively correlated with SOX9 expression, suggesting that SOX9 positively regulates this gene.