Table 1.

Summary of the number of in vivo toxicity studies evaluated for their relevance and reliability

	Studies assessed for their relevance	Studies considered relevant	Studies considered with reliability 1 and 2
			Relevant for hazard characterisation	Relevant for providing supporting evidence
Studies examining toxicity effect in the liver, spleen and pancreas	56	32	3	3
Studies examining toxicity effect in heart and kidney	27	10	3	2
Studies examining other organs	37	14	5	3
Reproductive and developmental toxicity studies	39	29	4	3
Neurotoxicity and developmental neurotoxicity studies	24	17	6	6
Inflammation and immunotoxicity studies	38	30	9	8
Gut microbiota	16	13		8