Table 2.

Parameters considered in the EOGRT study

Generation	F0	F0 satellite	F1 pups	F1 1A	F1 1B	F1 2A	F1 2B	F1 3	F2
Number of animals/sex per group	20	30		20	20	10	10	10
Mortality	X		X	X	X	X		X
Clinical signs	X			X	X	X		X
Body weight	X		X	X	X	X		X	X
Food consumption	X			X	X	X		X
Water consumption	X				X
Haematology	X			X
Clinical biochemistry	X			X
Lymphocyte typing (spleen)				X
Urinalysis	X			X
Sexual hormone levels	X			X	X	X	X
Thyroid hormone levels	X		X	X
Sexual maturation				X	X	X		X
Oestrous cycle data				X
Sperm parameters	X			X
Necropsy	X		X	X	X	X		X	X
Histopathology	X			X		X	X
Reproductive parameters	X		X		X
Pre‐postnatal development			X		X				X
Functional neurotoxicity observations						X
Neurohistopathology						X	X
Lymphocyte typing (spleen) after KLH immunisation				X				X
Anti‐KLH IgM levels after KLH immunisation								X
Aberrant crypt foci (ACF) scoring		X

EOGRT: extended one‐generation reproductive toxicity; KLH: keyhole limpet haemocyanin; IgM: immunoglobulin M.