| Reference | Test material | Scoring for nanoscale considerations (dispersion and/or confirmation of internal exposure), assigned according to Appendix E | Internal exposure |
|---|---|---|---|
| Talamini et al. ( 2019 ) | E 171 (35% nano), anatase, 201 nm in suspension (NTA) | 1 | Quantitative analysis in tissues with methodology reliable with some limitations |
| Coméra et al. ( 2020 ) | E 171, anatase, 20–340 nm (118 nm) (TEM); 44.7% particles < 100 nm | 1 | Quantitative analysis in tissue; methodology reliable with some limitations |
| Riedle et al. ( 2020 ) | E 171, anatase, 119 nm (TEM) | 1 | Qualitative analysis in tissues, methodology reliable with some limitations |
| Pele et al. ( 2015 ) | E 171, anatase, d50 = 260 nm | 1 | Qualitative analysis in blood, methodology highly reliable |
| Guillard et al. ( 2020 ) | E 171, anatase, 20–440 nm (mean 104.9 nm (SEM‐EDX), 55% nanoparticles | 1 | Quantitative analysis in tissues, methodology reliable with some limitations |
| Disdier et al. ( 2015 ) | TiO2 NPs, P25 (15–24 nm) | 1 | Quantitative analysis in blood and tissues, methodology reliable with some limitations |
| Kreyling et al. ( 2017a ) | TiO2 NPs, anatase, 50 nm (TEM), purity unknown | 1 | Quantitative analysis in blood and tissues; methodology highly reliable |
| Geraets et al. ( 2014 ) | NM‐100 (50–150 nm) and NM‐102 (21–22 nm) | 1 | Quantitative analysis in tissues; methodology highly reliable |
| Tassinari et al. ( 2014 ) | TiO2 NPs, anatase, two different morphologies: spherical shape with a size 20–60 nm (TEM) and irregular 60–40 nm (TEM) | 1 | Quantitative analysis in tissues; methodology highly reliable |
| Hendrickson et al. ( 2016 ) | TiO2 NPs, anatase, 20–25 nm (TEM) | 1 | Quantitative analysis in blood and tissue, methodology reliable with some limitations |
| Ammendolia et al. ( 2017 ) | TiO2 NPs, anatase, spherical shape 20–60 nm and irregular shape 40x60 nm (TEM) | 1 | Quantitative analysis in tissues, methodology highly reliable |
| Kreyling et al. ( 2017b ) | TiO2 NPs, anatase, 50 nm (TEM), purity unknown | 1 | Quantitative analysis in blood and tissue, methodology highly reliable |
| Hendrickson et al. ( 2020 ) | TiO2 NPs, rutile, needle‐ or rod‐like shape, 5 × 30 nm (TEM) | 1 | Particles identified in tissues by EM, methodology reliable with some limitations |
| Chen et al. ( 2020a , b ) | TiO2 NPs, anatase, 29 nm (SEM) | 1 | Quantitative analysis in blood and tissue, methodology reliable with some limitations |
| Heringa et al. ( 2018 ) | TiO2 particles | Not experimental study | Quantitative analysis in tissue, methodology highly reliable |
| Peters et al. ( 2020 ) | TiO2 particles | Not experimental study | Quantitative analysis in tissue, methodology highly reliable |
NTA: nanoparticle tracking analysis; SEM: scanning electron microscopy: TEM: transmission electron microscopy.