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. Author manuscript; available in PMC: 2021 May 6.
Published in final edited form as: Immunol Rev. 2020 Mar 25;295(1):15–38. doi: 10.1111/imr.12845

Fig. 1. Regulation of mTOR signaling pathways in T cells.

Fig. 1

Multiple signals from the TCR, co-stimulatory receptors, cytokines, growth factors, nutrients (amino acids, glucose, and nucleotides), oxygen, and DNA damage tune mTOR activation in T cells. In this figure, positive regulators are shown in ovals, and negative regulators are shown in squares; genes whose effects have been studied in genetic deletion systems are in red. Black solid arrows indicate an activating event, and black flat-ended arrows indicate an inhibitory event.