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. Author manuscript; available in PMC: 2021 May 6.
Published in final edited form as: Nat Chem Biol. 2020 Dec 16;17(1):10–19. doi: 10.1038/s41589-020-00700-7

Figure 3. cOA signalling in type III CRISPR system.

Figure 3.

Solid surface representation of the Csm complex (PDB ID: 6IFY) highlighting the Cas 10 domains involved in DNA cleavage (HD domain) and cOA synthesis (Palm domain) followed by a schematic showing the docking of cOA onto Csm6 and Csx1. Surface representation of Csm6 (PDB ID- 5FSH) and Csx1 (PDB ID - 6QZT) with the CARF domain responsible for cOA recognition shown in red and the HEPN RNase domain colored blue. Created with BioRender.com