. Author manuscript; available in PMC: 2021 May 6.

Published in final edited form as: Nat Chem Biol. 2020 Dec 16;17(1):10–19. doi: 10.1038/s41589-020-00700-7

Table 1.

Regulation of CRISPR-Cas gene expression

Regulator	CRISPR system	Key Mechanism
LRP⁶	IE - S. Typhi	Transcriptional repressor
H-NS^5,6	IE - S. Typhi, E.coli	Transcriptional repressor
leuO^5,6	IE - S. Typhi, E.coli	Relieves repression by LRP and H-NS
Csa3a⁷	IA - S. Islandicus	Transcriptional activator
Csa3b⁸	IA - S. Islandicus	Transcriptional repressor
CRP-cAMP⁹	IF - P. atrosepticum	Glucose responsive transcriptional activator
PvdS¹⁵	IF - P. aeruginosa	Iron responsive transcriptional activator
BaeSR¹⁰	IE - E.coli	Transcriptional activation likely in response to extracellular stress
LasR¹², RhlR¹²	IF - P. aeruginosa	Quorum sensing mediated transcriptional regulation
SmaR¹¹	I-E, I-F, IIIA - Serratia	Quorum sensing mediated transcriptional regulation
AlgU, AlgR, AmrZ¹³	IF - P. aeruginosa	Inhibition of CRISPR-Cas during planktonic growth
tr_L¹⁸	IIA - S. pyogenes	Repurposes Cas9 for autoregulation