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. 2021 Mar 19;5(5):e10481. doi: 10.1002/jbm4.10481

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© 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig 1 — Workflow for prioritizing 14 potential causal regulatory (Tier‐1) SNPs from 38 BMD GWAS. Summary of prioritization of plausible regulatory BMD SNPs. Abbreviations: Assoc, associated; BMD, bone mineral density; DHS, deoxyribonuclease I hypersensitive site; GREAT tool, http://great.stanford.edu/public/html/; GWAS, genome‐wide association study; H3K27ac, histone H3 lysine‐27 acetylation (an epigenetic mark of active enhancers or promoters); ostb, osteoblasts; SNP, single‐nucleotide polymorphism; TFBS, transcription factor binding site.