Fig 3.
NPR3, which codes for a natriuretic peptide clearance receptor, is associated with two downstream Tier‐1 SNPs. (A) NPR3 (chr5:32,678,200–32,856,800) and the BMD GWAS index and proxy SNPs (r 2 ≥ 0.8, EUR). (B) Tier‐1 SNPs. (C,D) Chromatin state segmentation and H3K27ac profiles as in Fig. 2. (E) Strand‐specific RNA‐seq (scale, 0–300). Broken arrow in C, ostb/chond/MSC‐specific TSS deduced from the CAGE signal for TSS; see Supplementary Fig. S8. Abbreviations: Adrenal gl, fetal adrenal gland (all other tissues are from adults); BMD, bone mineral density; chond, chondrocytes; GWAS, genome‐wide association study; MSC, mesenchymal stem cells; NHEK, skin keratinocytes; ostb, osteoblasts; SNP, single‐nucleotide polymorphism.