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. 2021 Mar 19;5(5):e10481. doi: 10.1002/jbm4.10481

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© 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig 4 — LGR4, which encodes a Wnt signaling receptor, has an intergenic Tier‐1 SNP far downstream of the gene. (A) LGR4 and surrounding genes (chr11:27,154,000‐27,560,000) and the BMD GWAS index and proxy SNPs as well as imputed SNPs. (B) The Hi‐C track⁽ ³⁷ ⁾ for chromatin folding for the fetal lung fib cell line IMR‐90; HMEC gave a similar profile (not shown). (C–E) As in Fig. 3 except that the minus‐strand signal is shown for RNA‐seq (scale, 0–100). Abbreviations: BMD, bone mineral density; fib, fibroblasts; GWAS, genome‐wide association study; HMEC, human mammary epithelial cells; Melano, foreskin melanocytes; SNP, single‐nucleotide polymorphism.