1. Haemodynamic outcome measures for comparator interventions reported by only one trial.
| Change in SBP after 30 minutes | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Nelson 1983 | 28 | ISDN versus frusemide | Fixed‐effect MD ‐6.00 mmHg, 95% CI ‐10.51 to ‐1.49 |
| Beltrame 1998 | 69 | NTG/NAC versus frusemide/morphine | Fixed‐effect MD ‐2.00 mmHg, 95% CI ‐21.49 to 17.49 |
| Change in SBP after 60 minutes | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Nelson 1983 | 28 | ISDN versus frusemide | Fixed‐effect MD ‐10.00 mmHg, 95% CI ‐12.62 to ‐7.38 |
| Beltrame 1998 | 69 | NTG/NAC versus frusemide/morphine | Fixed‐effect MD ‐4.00 mmHg, 95% CI ‐23.75 to 15.75 |
| Change in SBP after 3 hours | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| VMAC 2002 | 285 | NTG versus placebo | Fixed‐effect MD ‐3.20 mmHg, 95% CI ‐6.19 to ‐0.21 |
| VMAC 2002 | 347 | NTG versus nesiritide | Fixed‐effect MD ‐3.05 mmHg, 95% CI ‐3.05 to 2.85 |
| Beltrame 1998 | 69 | NTG/NAC versus frusemide/morphine | Fixed‐effect MD ‐2.00 mmHg, 95% CI ‐21.32 to 17.32 |
| Change in SBP after 24 hours | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Beltrame 1998 | 69 | NTG/NAC versus frusemide/morphine | Fixed‐effect MD ‐3.00 mmHg, 95% CI ‐21.94 to 15.94 |
| Change in DBP after 30 minutes | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Nelson 1983 | 28 | ISDN versus frusemide | Fixed‐effect MD ‐3.00 mmHg, 95% CI ‐5.22 to ‐0.78 |
| Change in DBP after 60 minutes | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Nelson 1983 | 28 | ISDN versus frusemide | Fixed‐effect MD ‐5.00 mmHg, 95% CI ‐7.22 to ‐2.78 |
| Change in HR after 30 minutes | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Nelson 1983 | 28 | ISDN versus frusemide | Fixed‐effect MD 0.00 bpm, 95% CI ‐3.35 to 3.35 |
| Beltrame 1998 | 69 | NTG/NAC versus frusemide/morphine | No significant difference reported |
| Change in HR after 60 minutes | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Nelson 1983 | 28 | ISDN versus frusemide | Fixed‐effect MD 1.00 bpm, 95% CI ‐2.35 to 4.35 |
| Beltrame 1998 | 69 | NTG/NAC versus frusemide/morphine | No significant difference reported |
| Change in HR after 3 hours | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Beltrame 1998 | 69 | NTG/NAC versus frusemide/morphine | Fixed‐effect MD ‐2.00 bpm, 95% CI ‐15.54 to 11.54 |
| Change in HR after 24 hours | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Beltrame 1998 | 69 | NTG/NAC versus frusemide/morphine | Fixed‐effect MD 10.00 bpm, 95% CI ‐2.78 to 22.78 |
| Change in PAOP after 3 hours | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| VMAC 2002 | 122 | NTG versus placebo | Fixed‐effect MD ‐1.80 mmHg, 95% CI ‐3.50 to ‐0.10 |
| VMAC 2002 | 184 | NTG versus nesiritide | Fixed‐effect MD 2.00 mmHg, 95% CI 0.24 to ‐3.76 |
| Change in PAOP after 18 hours | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| Verma 1987 | 24 | ISDN versus frusemide | Fixed‐effect MD 2.00 mmHg, 95% CI ‐3.34 to 7.34 |
| Change in PAOP after 24 hours | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| VMAC 2002 | 246 | NTG versus nesiritide | Mean reduction in PAOP was significantly greater with nesiritide (‐8.2 mmHg) than with NTG (‐6.3; P = 0.04) |
| Change in CO after 3 hours | |||
| Study ID | Number of participants | Comparator interventions | Measure of effects |
| VMAC 2002 | 184 | NTG versus placebo | Fixed‐effect MD 0.20 L/min/m2, 95% CI 0.00 to 0.40 |
| VMAC 2002 | 184 | NTG versus nesiritide | Fixed‐effect MD 0.10 L/min/m2, 95% CI ‐0.05 to ‐0.25 |
bpm: beats per minute CI: confidence interval CO: cardiac output HR: heart rate ISDN: isosorbide dinitrate MD: mean difference NAC: N‐acetylcysteine NTG: nitroglycerin PAOP: pulmonary artery occlusion pressure SBP: systolic blood pressure