Table 3. Patient outcomes by year of exposure with and without medication costs (Data source for Fig 4).

Incident Year	Years Before / After RA Diagnosis (n pairs), n biologics	RA Cases(2015 CAD/patient)	Age/Sex/Medical History Matched Controls (2015 CAD/patient)	Average Difference (2015 CAD/patient)	Sum of the Difference in Costs Since Diagnosis	Age/Sex Matched Controls (2015 CAD/patient)	Average Difference (2015 CAD/patient)	Sum of the Difference in Costs Since Diagnosis	Direct RA Associated Costs	Indirect RA Associated	Age/Sex Related Costs	RA Cases (2015 CAD/patient)	Age/Sex/Medical History Matched Controls (2015 CAD/patient)	Average Difference (2015 CAD/patient)	Sum of Difference in Costs Since Diagnosis	Age/Sex Matched Controls (2015 CAD/patient)	Average Difference (2015 CAD/patient)	Sum of Difference in Costs Since Diagnosis	Direct RA Associated Costs	Indirect RA Associated	Age/Sex Related Costs
	A. Total Costs with Medications											B. Total Costs without Medications
2002	-8 (n = 5,322),	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
	0
	-5 (n = 5,322),	1503	1522	-19	-3422	1007	496	-4129	-19	515	1007	1287	1289	-2	-3258.5	849	438	-3874	-2	440	849
	0
	-2 (n = 5,322),	1735	1685	50	-3353	1086	649	-3967	50	599	1086	1353	1294	59	-3198	829	523	-3789	59	465	829
	0
	-1 (n = 5,322),	2109	1855	254	-3151	1218	891	-3736	254	637	1218	1632	1405	227	-3030	906	725	-3587	227	499	906
	0
	0	6870	3466	3404	0	2243	4627	0	3404	1223	2243	6178	2921	3257	0	1867	4312	0	3257	1054	1867
	(n = 5,322), <8
	1	6617	4360	2257	-1147	3297	3320	-1306	2257	1063	3297	5686	3739	1947	-1310	2865	2820	-1492	1947	874	2865
	(n = 5,322), 11
	2	6851	4576	2275	-1129	3436	3415	-1211	2275	1140	3436	5736	3901	1835	-1422	2960	2275	-2037	1835	941	2960
	(n = 5,322), 24
	5	8095	5630	2465	-939	4106	3989	-636	2465	1524	4106	6735	4870	1865	-1392	3549	3186	-1126	1865	1321	3549
	(n = 5,322), 31
	8	7829	5792	2037	-1366	4428	3401	-1225	2037	1364	4428	6334	5006	1328	-1929	3833	2501	-1811	1328	1173	3833
	(n = 5,322), 27
2009	-8	1294	1271	23	-4609	926	368	-5060	23	345	926	1059	1038	21	-4350.4	751	309	-4713	21	287	751
	(n = 6637)
	-
	-5 (n = 6637), <8	2653	2618	35	-4597	1877	776	-4653	35	741	1877	2219	2230	-11	-4384	1591	628	-4394	-11	639	1591
	-2 (n = 6637), <8	4215	3790	425	-4207	2793	1422	-4007	425	997	2793	3586	3245	341	-4030	2377	1209	-3813	341	868	2377
	-1 (n = 6637),	5066	4032	1034	-3598	3202	1864	-3565	1034	830	3202	4352	3430	922	-3450	2734	1618	-3404	922	696	2734
	8
	0	9136	4504	4632	0	3707	5429	0	4632	797	3707	8201	3828	4373	0	3179	5022	0	4373	649	3179
	(n = 6637), 20
	1	8563	5136	3426	-1206	4080	4483	-946	3427	1056	4080	7430	4458	2972	-1400	3548	3882	-1140	2972	910	3548
	(n = 6637), 45
	2	8198	5158	3040	-1592	4235	3963	-1466	3040	923	4235	6859	4475	2384	-1988	3735	3124	-1898	2384	740	3735
	(n = 6637), 91
	5	8373	5293	3080	-1553	4482	3890	-1539	3080	811	4482	6440	4544	1896	-2476	3864	2577	-2445	1896	680	3864
	(n = 6637), 66
	8	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-