Fig 8. Disruption of autophagy contributes to accumulation of ubiquitin-positive compartments in the vps24 mutant.

Confocal immunofluorescence images of CNS neurons (A) and DLM (B) from WT (a-d) or the vps24 mutant (e-h). Localization of endogenous P62, the autophagy adaptor protein, was used to mark intermediates in autophagy. In both neurons and muscle, the vps24 mutant exhibits accumulation of P62. The distribution of P62 overlaps with but is more punctate and restricted than that of the ubiquitin-positive compartment.